Save or Splurge? The Ordinary EUK 134 vs. NIOD Superoxide Dismutase Saccharide Mist

Which DECIEM option should you go with: The Ordinary's EUK 134 or NIOD's superoxide dismutase saccharide mist?

Despite all the recent-ish drama surrounding the future of The Ordinary, DECIEM is taking the world by storm. Here in NYC, there are now seven locations—I still remember there were only two stores around a half year ago (~March or April), when I first visited the location in SoHo. Here’s a drive-by picture of the new Upper West Side location:

The Ordinary EUK 134 vs. NIOD Superoxide Dismutase Saccharide Mist

You may or may not know that DECIEM is the parent company of several beauty brands, ranging from the budget-friendly The Ordinary to the more $$$ NIOD brand. Maybe this is something people learn in business school, but I always wonder why companies choose to make two products that claim to provide similar benefits, but sell them at drastically different price points. Aren’t they afraid that everyone will just default to the more affordable option? This is actually a long-winded introduction to today’s post, which will aim to answer a very interesting question from a My Dad the Chemist reader.

Eva was having trouble deciding between two similar products from DECIEM: The Ordinary EUK 134 and NIOD Superoxide Dismutase Saccharine Mist. She left the following comment on my comparison of The Ordinary Niacinamide 10% + Zinc 1% vs. Paula’s Choice RESIST 10% Niacinamide Booster:

Let’s unpack a few ideas from the support team’s response before we go any further.

What is superoxide dismutase?

I did a bit of digging about superoxide dismutase, and discovered that this is actually a class of antioxidants that fight superoxide radicals by converting them to oxygen and hydrogen peroxide. Superoxide radicals are responsible for bad things like inflammation and damage to DNA (hence, the support team’s suggestion that this compound can help improve the quality of your skin by fighting inflammation and other signs of stress.

How does EUK 134 compare to superoxide dismutase?

EUK 134 is a “mimetic” of superoxide dismutase, the potent antioxidant found in NIOD’s dermal treatment mist. What is a mimetic? A mimetic is basically a substance that mimics the actions/properties of another naturally occurring substance (in this case, the antioxidant known as superoxide dismutase). In fact, there’s a whole field known as biomimetic chemistry, which focuses on creating new compounds modeled after naturally occurring biological compounds and processes. Like how snow machines mimic real-life weather. Kinda. You can probably think of a more fitting example…but I digress.

The question is, can a mimetic like EUK 134 be just as effective as superoxide dismutase, the antioxidant it’s designed to mimic? Let’s dig deeper.

The Ordinary EUK 134 ingredients

NIOD Superoxide Dismutase Saccharide Mist ingredients

My Dad the Chemist’s review of The Ordinary EUK 134 vs. NIOD Superoxide Dismutase Saccharide Mist

It looks like my dad hasn’t worked with any skincare products that contain this key ingredient, superoxide dismutase. But he was intrigued enough to do some research (not every question of mine inspires him to take action, so this is saying something!), and he thought that the clinical test results indicated that EUK 134 was an effective alternative to superoxide dismutase. Therefore, he recommends trying The Ordinary EUK 134 over NIOD Superoxide Dismutase Saccharide Mist. Yay for saving money but still getting results!

the ordinary euk 134 vs niod superoxide dismutase saccharide mist

You might still have one question lingering in your mind, though…

Is The Ordinary EUK 134’s low percentage of EUK 134 something to worry about?

I asked my dad about the low percentage of ethylbisiminomethylguaiacol manganese chloride (EUK 134). I also wanted to see if he thought it was a problem that the rest of this serum (99.9%) consists of propanediol. Here was his response:

My dad thinks that superoxide dismutase is very potent, so it generally isn’t used at high concentrations to begin with. Since EUK 134 is a mimetic of superoxide dismutase (again, a very potent compound), it could even be more potent and stable than the compound it’s meant to mimic. Therefore, he thinks that The Ordinary EUK 134 may be effective even at a low concentration of 0.1 percent. Plus, the rest (99.9 percent) of the formula isn’t bad for you either. It turns out that propanediol is also a beneficial ingredient, since it’s a naturally derived humectant that’s effective for providing long-lasting moisturizing properties.

So there you have it. In this case, it pays to “save” rather than splurge: Try The Ordinary EUK 134 before you shell out the big bucks for NIOD Superoxide Dismutase Saccharide Mist. If you don’t see results from this mimetic form of superoxide dismutase, then, by all means, try out the more premium “dermal treatment mist” (even the name sounds pretty frou frou) from NIOD.

Note that The Ordinary does not recommend mixing EUK 134 with acids, such as a Vitamin C serum, mandelic acid, or AHA 30% + BHA 2%.

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